Thursday, January 31, 2013

The 787's Problems Run Deeper Than Outsourcing - James Allworth ...

The 787 Dreamliner was supposed to be a big jump forward for Boeing ? notably, the first plane to be made entirely of composites rather than aluminum. It consumes 20% less fuel than an equivalent 767; which, given today's increasing fuel prices and airlines' diminishing profit margins, should make it an extremely desirable aircraft.

Unfortunately, things haven't quite worked out as planned.

While the first 787 was originally scheduled to be delivered back in 2008, a string of delays and cost overruns meant that deliveries didn't start until 2011. Boeing looked to have turned the corner with the 787 once deliveries had started, but since launch it has been plagued with a number of high-profile problems ? fuel leaks, smoke in the cabin, and fires. The troubled plane has been grounded as global regulators investigate whether it's safe to fly.

Now, it is true that problems like these are always a feature of new plane launches. But the extent to which the 787 has been troubled both in gestation and post-launch suggests that something more is at work. Boeing undertook one of the most extensive outsourcing campaigns that it has ever attempted in its history. That decision has received a lot of press coverage, and the common wisdom is coalescing around this as a cause of the problems.

But Boeing is no stranger to subcontracting. And while outsourcing can certainly lead to problems, I'm not convinced it's the cause of these problems. Outsourcing leads to business model risk ? you open the door to outsourcing your profits (in fact, a 2001 Boeing paper that is incredibly prescient and worth the time to read identified exactly this problem). But this isn't the problem that the 787 is suffering from. At least not yet.

Rather, the issues the plane has been facing have much more to do with Boeing's decision to treat the design and production of such a radically new and different aircraft as a modular system so early in its development.

In the creation of any truly new product or product category, it is almost invariably a big advantage to start out as integrated as possible. Why? Well, put simply, the more elements of the design that are under your control, the more effectively you're able to radically change the design of a product ? you give your engineers more degrees of freedom. Similarly, being integrated means you don't have to understand what all the interdependencies are going to be between the components in a product that you haven't created yet (which, obviously, is pretty hard to do). And, as a result of that, you don't need to ask suppliers to contract over interconnects that haven't been created yet, either. Instead, you can put employees together of different disciplines and tell them to solve the problems together. Many of the problems they will encounter would not have been possible to anticipate; but that's ok, because they're not under contract to build a component ? they've been employed to solve a problem. Their primary focus is on what the optimal solution is, and if that means changing multiple elements of the design, then they're not fighting a whole set of organizational incentives that discourage them from doing it.

Conversely, if you're trying to modularize something ? particularly if you're trying to do it across organizational boundaries ? you want to be absolutely sure that you know how all the pieces optimally work together, so everyone can just focus on their piece of the puzzle. If you've done it too soon and tried to modularize parts of an unsolved puzzle across suppliers, then each time one of those unanticipated problems or interdependencies arises, you have to cross corporate boundaries to make the necessary changes ? changes which could dramatically impact the P&L of a supplier. Lawyers will probably need to get involved. So too might the other suppliers, who could quite possibly be required to change the design of their component, also (chances are, you've already contracted with them, too). The whole thing snowballs.

Historically, Boeing understood that, and had worked with its subcontractors on that basis. If it was going to rely on them, it would provide them with detailed blueprints of the parts that were required ? after Boeing had already created them. That, in turn, meant that Boeing had to design all the relevant pieces of the puzzle itself, first. But with the 787, it appears that Boeing tried a very different approach: rather than having the puzzle solved and asking the suppliers to provide a defined puzzle piece, they asked suppliers to create their own blueprints for parts. The puzzle hadn't been properly solved when Boeing asked suppliers for the pieces. It should come as little surprise then, that as the components came back from far-flung suppliers, for the first plane ever made of composite materials... those parts didn't all fit together. Time and cost blew out accordingly.

It's easy to blame the outsourcing. But, in this instance, it wasn't so much the outsourcing, as it was the decision to modularize a complicated problem too soon.

Boeing's experience bears comparing to another company, one which has mastered the art of managing design as an integrated process, while still utilizing outsourcing ? Apple. Apple doesn't manufacture their own products; but anyone who has used an Apple device can tell you that having someone else doing the manufacturing hasn't compromised the quality of the product at all. But Apple treats both the design process and its suppliers very differently to the way that Boeing does ? or at least did, in the case of the 787.

Two key questions remain:

Has Boeing learned from the mistake? Recent comments from their leadership suggest that they may have: Jim Albaugh, who only just retired as the company's commercial aviation chief after a 35 year career with Boeing, noted that "in hindsight, we spent a lot more money in trying to recover than we ever would have spent if we tried to keep many of the key technologies closer to Boeing. The pendulum swung too far." The company's Chief Executive, Jim McNerney, said that he "would draw the lines in a different place" ? but don't mistake that for ditching the outsourcing, because he also said that he "would still have the same supplier/partner concept."

And why did Boeing decide to do this in the first place? The New Yorker provides some context on this question ? and it relates to McDonnell Douglas. While ostensibly Boeing took over McDonnell Douglas, what really happened was more akin to a reverse takeover ? McDonnell Douglas took over Boeing. Several of the top positions in the merged Boeing were assigned to executives who had previously worked in St. Louis, where the heritage of McDonnell Aircraft had been one of fighter and attack aircraft for the military. The thing about these Government contracts is that they are paid as development proceeds. This is entirely different ? and a lot less risky ? than the development model for a traditional commercial airliner, where an aerospace company needs to find all the capital. My hypothesis is that McDonnell's mindset from its defense work ? minimizing the amount of capital put at risk during R&D ? was applied to the 787.

They didn't want to pay full price for the Dreamliner's development, so, they didn't ? or at least, that's what they thought. But as Henry Ford warned almost a century earlier: if you need a machine and don't buy it, then you will ultimately find that you have paid for it and don't have it.

Source: http://blogs.hbr.org/cs/2013/01/the_787s_problems_run_deeper_t.html

washington nationals Gary Collins bus driver uppercut Argo Alex Karras BCS Rankings 2012 the walking dead

Wednesday, January 30, 2013

Tara Stiles: Totally Enlightened!

Totally Enlightened! is a story of two BFFs trying to find inner peace in all the wrong places. I wrote this as a short film about 10 years ago when I moved to NYC and started dipping my toes in all the different yoga and spiritual communities that were hanging around, and I observed quite a few comedic moments in the process. What fun is life if it's taken so seriously, and what fun is yoga and the search for enlightenment if we are tight, tense, and clenched up from the inside out? The moral is what you make of it. My intention is to remind us all that the guru is within, and our intention will guide the way, whether we are sipping expensive organic tea blessed by a monk or not. Enjoy!

Big thanks to Demand Media, and all the Hollywood pros and NYC friends and Strala regulars who made this possible.

For more by Tara Stiles, click here.

For more on yoga, click here.

?

?

?

Follow Tara Stiles on Twitter: www.twitter.com/tarastiles

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/tara-stiles/yoga-humor_b_2563851.html

donovan mcnabb lottery ticket megga millions what is autism the giver march 30 rimm

X-Rite ColorMunki Display

By John R. Delaney

If you took your monitor out of the box, hooked it up, and set it to any one of the available picture presets, there's a good chance that it needs to be calibrated. Fuzzy image detail and inaccurate colors are the most obvious signs that something is not right, but there are other side effects of an un-calibrated monitor, such as when your monitor's output doesn't match your printer's output, or when images look different on your laptop screen than they do on your desktop monitor. Fortunately, there are calibration tools available that will have all of your monitors and laptops looking their best without spending a fortune. The X-Rite ColorMunki Display is one such tool. Using a combination of hardware and software, the ColorMunki makes calibrating monitors, laptops, and projectors quick and painless. The wizard-driven software offers excellent text and video help, but chances are, you won't need it as the ColorMunki is very easy to use. More importantly, it delivers the goods, providing a profile that will let your monitor deliver consistent color quality and luminance levels. My gripes with the ColorMunki Display are minor; the colorimeter needs a longer USB cord and the software lacks charting capabilities. Neither issue prevents it from earning our Editors' Choice for monitor calibration tools.

Design and Features
Like the Datacolor Spyder4 Pro, the ColorMunki Display uses a colorimeter to measure color and software that tells the meter what to measure. The software guides you through the calibration process, makes changes to your video card's LUT (Look Up Table), and saves these results as a profile which your monitor uses to display consistent and accurate colors. The ColorMunki can calibrate CRT and LCD monitors and laptops, and it can also calibrate projectors, a feature missing in the Spyder4 Pro.

The ColorMunki is compact, measuring 2.5-by-2.5-by-1.5 inches (HWD). It sports a glossy black and matte black finish with the ColorMunki logo on both sides. A light diffuser is positioned over the meter's optical lens. It's used to measure ambient light and to protect the lens when not in use. It also acts as a stand for measuring desktop projectors. When it comes time to measure your monitor's color and luminance levels, simply slide the diffuser up and rotate it to the bottom of the meter.

The colorimeter connects to your PC via a 70-inch USB cable with an adjustable weight. Although it's few inches longer than the cord used on the Spyder4 Pro (67 inches) it is still a bit too short for users who have floor-standing desktop towers. White LED activity indicators are embedded on both sides of the meter, and there's a mounting receptacle on the bottom for use with a tripod. To use the ColorMunki on a laptop or monitor, hang the meter over the front of the screen with the weight resting on the back of the cabinet. The weight holds the meter in place and keeps it flush against the panel.

The ColorMunki can be used on multiple monitors and projectors and the software can be installed on multiple PCs. It features an ambient light sensor to determine the best levels for your lighting environment and offers basic and advanced user modes. The basic mode is fully automated and adjusts everything for you, including brightness, using the ADC (Automatic Display Control), a feature lacking in the Spyder4 Pro. It also offers Ambient Light Monitoring, which checks your surrounding lighting conditions throughout the day and makes adjustments based on the new levels.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/6aibBoAIQKE/0,2817,2414919,00.asp

Allegiant Air Melissa Rycroft mega millions Cyber Monday Deals 2012 Sasha McHale Boy Meets World elizabeth taylor

Samsung Galaxy Tab 3 And Variants Confirmed In UAPROF Files

Samsung has a little bit of something for everyone when it comes to tablets, and the Samsung Galaxy Tab 3 would be the next big thing that the South Korean consumer electronics giant intends to announce. So far, Samsung?s very own UAPROF (User Agent Profile) files for the Samsung GT-P3200, GT-P5200 and GT-P8200 have been announced, revealing additional details such as the screen resolution along the way. Surely it is time for a new Galaxy Tab 3 to hit the market instead of relying on a rehash of color schemes?

?

?From what we have gathered so far, the Galaxy Tab 3 7.0?/8.0? will not have that stunning a display if you are going to bring home the entry level model, as it sports a screen resolution of 1024 ? 600. Well, if you decide to opt for the larger sized Galaxy Tab 3 10.1?, that puppy will be easier on your eyes due to its size and 1280 ? 800 resolution.

For those who want nothing but the very best, then you would do well to settle for the Galaxy Tab 3 Plus that has a stunning resolution of 2560 ? 1600 pixels which would clearly place it in Retina Display category. Just in case you were wondering, 2560 x 1600 pixels would be the same resolution as that of the Nexus 10.

Chances are pretty high that Samsung will be introducing the trio of tablets at Mobile World Congress at Barcelona at the end of next month, and we fully intend to hit the showfloor and bring you hands-on images and experiences.

Source: http://www.androidpit.com/samsung-galaxy-tab-3-and-variants-confirmed-in-uaprof-files

edgar vs henderson berkshire hathaway ufc 144 james jones james jones aladdin black forest

Tuesday, January 29, 2013

Altering eye cells may one day restore vision

Jan. 25, 2013 ? Doctors may one day treat some forms of blindness by altering the genetic program of the light-sensing cells of the eye, according to scientists at Washington University School of Medicine in St. Louis.

Working in mice with retinitis pigmentosa, a disease that causes gradual blindness, the researchers reprogrammed the cells in the eye that enable night vision. The change made the cells more similar to other cells that provide sight during daylight hours and prevented degeneration of the retina, the light-sensing structure in the back of the eye. The scientists now are conducting additional tests to confirm that the mice can still see.

"We think it may be significantly easier to preserve vision by modifying existing cells in the eye than it would be to introduce new stem cells," says senior author Joseph Corbo, MD, PhD, assistant professor of pathology and immunology. "A diseased retina is not a hospitable environment for transplanting stem cells."

The study is available in the early online edition of Proceedings of the National Academy of Sciences.

Mutations in more than 200 genes have been linked to various forms of blindness. Efforts are underway to develop gene therapies for some of these conditions.

Rather than seek treatments tailored to individual mutations, Corbo hopes to develop therapies that can alleviate many forms of visual impairment. To make that possible, he studies the genetic factors that allow cells in the developing eye to take on the specialized roles necessary for vision.

The retina has two types of light-sensing cells or photoreceptors. The rods provide night vision, and the cones sense light in the daytime and detect fine visual details.

In retinitis pigmentosa, the rods die first, leaving patients unable to see at night. Daytime vision often remains intact for some time until the cones also die.

Corbo and others have identified several genes that are active in rods or in cones but not in both types of photoreceptors. He wondered whether turning off a key gene that is activated only in rods could protect the cells from the loss of vision characteristic of retinitis pigmentosa.

'"The question was, when retinitis pigmentosa is caused by a mutation in a protein only active in rods, can we reduce or stop vision loss by making the cells less rod-like?" he explains.

The new study focuses on a protein known as Nrl, which influences development of photoreceptors. Cells that make Nrl become rods, while cells that lack the protein become cones. Turning off the Nrl gene in developing mice leads to a retina packed with cone cells.

To see if this rod-to-cone change was possible in adult mice, Corbo created a mouse model of retinitis pigmentosa with an Nrl gene that could be switched on and off by scientists.

"In adult mice, switching off Nrl partially converts the rod cells into cone cells," he says. "Several months later, when the mutant mice normally had very little vision left, we tested the function of their retina."

The test showed a healthier level of electrical activity in the retinas of mice that lacked Nrl, suggesting that the mice could still see.

Corbo now is looking for other critical development factors that can help scientists more fully transform adult rods into cones. He notes that if complete conversion of rods to cones were possible, this therapy could also be helpful for conditions where cone cells die first, such as macular degeneration.

Montana CL, Kolesnikov AV, Shen SQ, Myers CA, Kefalov VJ, Corbo JC. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proceedings of the National Academy of Sciences, online January 14, 2013.

Funding from the National Eye Institute (EY018826 and EY019312), an Institutional Vision Science Training Grant (EY13360) and a grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences at Washington University supported this research.?

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Washington University in St. Louis. The original article was written by Michael C. Purdy.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. C. L. Montana, A. V. Kolesnikov, S. Q. Shen, C. A. Myers, V. J. Kefalov, J. C. Corbo. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1214387110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/bmQWAsLKO80/130128104443.htm

ted nugent veep los angeles kings earth day timothy leary jonathan frid pujols

Monday, January 28, 2013

More Than Meets the Eye About Death, Dying, and Afterlife: The ...

By Nelson Berry

One of the hardest things in life that you have to deal with is death in the family. Perhaps you already know that there's no easy way to say good-bye. However, you also don't want to miss the moment to do so.

There are no golden rules, but you can take heed of the following steps:

1. Remind them of the good things they've done. Even at their last moments, you definitely want them to feel that their lives are not in vain. They have contributed something not just to you but to the rest of the world. Talk about the good things and the pleasant memories. You can create a scrapbook or an album you can show to the dying. He or she can then turn the pages if he or she wishes to reminisce.

2. Don't treat the person too differently. Families and friends tend to treat the dying with a lot of pity and sadness. Unknown to you, the dying actually has a very excellent observation skill. They can easily detect if it's too hard for you to let go. In turn, it will be hard for them to say good-bye. Don't see them as totally different person. As hard as it may be, act as you usually do when he or she is still completely well.

3. Allow them to say good-bye. It's not only you who has to say good-bye. A lot of dying patients want to take the opportunity to do that too. After all, they are the ones who are going to do the leaving. It's essential you give them the liberty to bid farewell. Don't say, "You are still not dying" or "You still have a lot of days to live." You are only making things harder for them.

4. Listen very carefully. There are a lot of things the dying would like to talk to you. Perhaps there are still some activities they wish to accomplish, people they wish to see, or they just want to reflect on the possible death they are going to experience. Just be there to listen. There's really no need to give some advice unless he or she asks you.

5. Be there when the time comes. The dying may tell you they want to go alone, but the truth is it makes them really scared. So be there for them at the moment of death. It's going to be quite difficult, but it's one of the best things you can do for the beloved. Your inner strength may also be needed by friends and family who have weaker hearts than yours.

6. Keep yourself strong. Strength is one of the things you definitely need when you're about to face grief. When you know that it starts to dissipate, just use subliminal messages. There are many subliminal messages you can recite before seeing the dying or when you're meditating. These subliminal messages may be the following:

I am blessed by the friendship and love of (name of the dying).
I accept the process of death and grief.
I embrace the pain.

Nelson Berry is The Pioneer of Subliminal Messages Audio & Video Online and Subliminal Messages Expert for More Than Two Decades! You Love The Way That YOUR Life *Flows* and LOVE the Feelings, Fun, Fortune and Happiness it gives YOU! YOUR Dreams Really Do Come True!! Click Here for a FREE Subliminal Messages Video Download ($39.95 Value) Right Now -- Today! Try It: http://www.subliminalmessagesdownloads.com

Article Source: http://EzineArticles.com/?expert=Nelson_Berry

~~~~~~~~~~~~~~~~~~~
For more information, you might enjoy reading my book,?More Than Meets the Eye True Stories about Death, Dying, and Afterlife.?Purchase paperback on Amazon.com. It's also on Amazon as an e-book for those who have Kindle or Sony Readers. The audio book is now available!
~~~~~~~~~~~~~~~~~~~

Source: http://deathdyingafterlife.blogspot.com/2013/01/the-dying-process-how-to-properly-say.html

south by southwest i want to know what love is courtney mercury retrograde bath salts heart shaped box lucid

Say Anything In The Legislature Today: Property Tax Reforms And ...

I posted earlier today about the reduction in the state sales tax proposed by Rep. Rick Becker which will be heard before the House Finance and Tax Committee. Here are some other bills also being heard today:

HB1199, introduced by Rep. Jeff Delzer, would require that cities, counties and school districts pass their budget and tax levy in a manner that allows them to be referred by the public if a petition with signatures amounting to 10% of the qualified electors of that city/county/school district is filed.

HB1239, introduced by Rep. Ben Koppelman, would cap property valuation increases at no more than 3% a year. From the bill:

Notwithstanding any other provision of law, the taxable valuation on any parcel of taxable property may not exceed by more than three percent the amount of the taxable valuation on that parcel of taxable property in the preceding taxable year, except to the extent improvements to the property have been made which were not included in the taxable valuation of the property in the previous taxable year.

HB1373, introduced by Rep. Rick Becker, would regulate law enforcement?s use of surveillance drones requiring them to obtain a warrant except in exigent circumstances such as a natural disaster or while searching for a missing person.

Tags: ben koppelman, jeff delzer, North Dakota News, property taxes, rick becker, surveillance drones

Rob Port

Rob Port is the editor of SayAnythingBlog.com. In 2011 he was a finalist for the Watch Dog of the Year from the Sam Adams Alliance and winner of the Americans For Prosperity Award for Online Excellence. He writes a weekly column for several North Dakota newspapers, and also serves as a policy fellow for the North Dakota Policy Council.

Source: http://sayanythingblog.com/entry/in-the-legislature-today-property-tax-reforms-and-drone-regulation/

elite eight stephon marbury the lion king suzanne collins cherry blossom festival nc state erika van pelt

Sunday, January 27, 2013

Camco 36153 RV Brass Blow Out Plug Reviews

List price: $ 6.71

Camco 36153 RV Brass Blow Out Plug

  • Helps clear the water lines in your RV during winterization and dewinterization
  • Built with brass
  • Screws into RV city water inlet
  • Heavy duty
  • Easy to use

Completely clear your water lines with the Camco RV Brass Blow Out Plug. Screw the plug into the city water inlet, open all drains and faucets, attach and activate the air pump until all lines are clear. Patented.

Source: http://atixi.com/camco-36153-rv-brass-blow-out-plug-reviews/

stop sopa justified southland sopa blackout protect ip act jim caldwell internet blackout

Dozens reported killed in Venezuela prison riot

CARACAS, Venezuela (AP) ? Venezuelan authorities promised a high-level investigation Saturday into a deadly prison riot that reportedly left dozens of people dead when National Guard soldiers clashed with armed inmates.

Vice President Nicolas Maduro called the violence tragic while speaking on television early Saturday and said Prosecutor General Luisa Ortega Diaz and National Assembly President Diosdado Cabello would lead the investigation. He and other officials didn't give a death toll from the riot Friday at Uribana prison in the central Venezuelan city of Barquisimeto.

"The prisons have to be governed by law," Maduro said.

Humberto Prado, an activist who leads the watchdog group Venezuelan Prisons Observatory, said inmates' relatives and media accounts put the toll at 55 killed and 88 injured.

The Venezuelan newspaper Ultimas Noticias and the television channel Globovision reported more than 50 killed, both citing Ruy Medina, the director of Central Hospital in the city.

Relatives wept outside the prison during the violence, and cried at the morgue Saturday as they waited to identify bodies.

Penitentiary Service Minister Iris Varela said Friday that the riot broke out when groups of inmates attacked National Guard troops who were attempting to carry out an inspection.

Varela said the violence had affected a number of prisoners and officials, but said the authorities would hold off until control had been re-established at the prison to confirm the toll. She said the government decided to send troops to search the prison after receiving reports of clashes between groups of inmates during the past two days.

The death toll provided by Medina rose late Friday after he had initially reported four killed and dozens injured. Ultimas Noticias reported that the victims included a Protestant pastor and a member of the National Guard, as well as inmates.

Opposition leader Henrique Capriles condemned the government's handling of the country's overcrowded and violent prisons.

"Our country's prisons are an example of the incapacity of this government and its leaders. They never solved the problem," Capriles said on his Twitter account. "How many more deaths do there have to be in the prisons for the government to acknowledge its failure and make changes?"

The Venezuelan Prisons Observatory said in a statement that in 2007 the Costa Rica-based Inter-American Court of Human Rights had ordered the government to seize weapons that inmates had in their possession at Uribana prison and to take measures to avoid deaths in the facility. The group called for the government to release a list with the names of the dead and wounded in Friday's violence, as well as details about weapons seized in the search.

"No one doubts that inspections are necessary procedures to guarantee prison conditions in line with international standards, but they can't be carried out with the warlike attitude as (authorities) have done it," Prado told The Associated Press in a telephone interview. "It's clear that the inspection wasn't coordinated or put into practice as it should have been. It was evidently a disproportionate use of force."

Prado's group says Uribana prison was built to hold up to 850 inmates but currently has about 1,400.

It was the latest in a series of bloody riots in the country's severely overcrowded prisons where inmates often freely obtain weapons and drugs with the help of corrupt guards. Venezuela currently has 33 prisons built to hold about 12,000 inmates, but officials have said the prisons' population is about 47,000.

In April and May, a prison uprising in La Planta prison in Caracas blocked authorities from going inside for nearly three weeks. One prisoner was killed and five people were wounded, including two National Guard soldiers and three inmates.

Two months later, another riot broke out at a prison in Merida, and the Venezuelan Prisons Observatory reported 30 killed.

In August, 25 people were killed and 43 wounded when two groups of inmates fought a gunbattle inside Yare I prison south of Caracas.

Chavez's government has previous pledged improvements to the prison system, but opponents and activists say the government hasn't made progress.

Source: http://news.yahoo.com/dozens-reported-killed-venezuela-prison-riot-171656137.html

Ebates lotto Illinois Lottery texas lottery Dell Levis Fireman Ed

Bahrain police, mourners clash after boy's funeral

MANAMA, Bahrain (AP) ? Riot police and mourners have clashed in Bahrain following the funeral of an 8-year-old boy whom opposition groups claim died from respiratory problems triggered by heavy tear gas.

Officials did not immediately comment on the cause of the boy's death after he was hospitalized Jan. 19.

Rights groups and others have complained about intense tear gas use by Bahraini forces during nearly two years of unrest.

Hundreds of mourners staged a protest march following Sunday's burial, but were dispersed by riot police firing tear gas and stun grenades. Some protesters hurled firebombs.

Bahrain has been wracked by conflict between the Sunni-led monarchy and majority Shiites seeking a greater political voice.

More than 55 people have died in the unrest in the strategic kingdom, home to the U.S. Navy's 5th Fleet.

Source: http://news.yahoo.com/bahrain-police-mourners-clash-boys-funeral-160130827.html

new york post kate middleton bob costas bowl projections Jovan Belcher Charlie Batch Rita Ora

Saturday, January 26, 2013

Facebook preventing Twitter's Vine from finding friends

21 hrs.

Twitter's Vine officially launched on Thursday and things have already been fairly rough for the?new video-sharing service. First we noticed that it seems to lack any proper privacy settings or features and now it seems as if Facebook's preventing Vine from finding any friends.

As the Verge's Jeff Blagdon points out, some Twitter users are calling attention to an error message which appears when they attempt to find Facebook friends on Vine. "Vine is not authorized to make this Facebook request," the message explains.

We reached out to both Facebook and Twitter to find out more about this error message. A Twitter spokesperson responded with a polite message pointing us to a post on the official Facebook developers blog. (Yes, yes. This made us chuckle for a moment, too.)

In the blog post, Facebook's Justin Osofsky, director of platform partnerships and operations, clarifies some of the social network's platform policies.?He basically explains that most apps use Facebook's platform to give people an easy way to log into apps, easily share content and so on. But, he writes, there is a small number of apps which are "using Facebook to either replicate [its] functionality or bootstrap their growth in a way that creates little value for people on Facebook."

"[W]e?ve had policies against this that we are further clarifying today," he writes, linking to the social network's platform policies page, which explains why Vine's cut off:

Facebook Platform enables developers to build personalized, social experiences via the Graph API and related APIs. If you use any Facebook APIs to build personalized or social experiences, you must also enable people to easily share their experiences back with people on Facebook. [...]?You may not use Facebook Platform to promote, or to export user data to, a product or service that replicates a core Facebook product or service without our permission.

In other words: No, Vine. You can't make friends by leaning on Facebook.

Of course, this siliness?is just the latest skirmish in a long battle over "friends" between Facebook and Twitter.?Facebook blocked Twitter's access to the social network's in-app friend finder in mid-2010 and Twitter later killed Instagram's ability to find friends easily. (Instagram, as you may remember, is now owned by Facebook.

Guess it's Twitter's turn to do something again.

Want more tech news?or interesting?links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts,?or circling her?on?Google+.

Source: http://www.nbcnews.com/technology/technolog/facebook-preventing-twitters-vine-finding-friends-1C8119018

rich ross april 20 jennifer love hewitt secret service prostitution 4 20 george zimmerman sheree whitfield

H&R Block At Home Deluxe Online (Tax Year 2012)


No personal tax preparation software/website publisher has a range of offerings as broad as H&R Block, understandably. Industry veteran Intuit is a relative upstart compared to H&R Block, which has been providing tax services since 1955. The company employs more than 100,000 tax professionals worldwide and has prepared more than 550 million tax returns worldwide. This year, we've reviewed H&R Block At Home Deluxe Online .

H&R Block's digital presence is considerable. It has competed alongside Intuit and 2nd Story Software for years, first as a publisher of personal tax preparation software, and then as the host for matching websites. You can use these products entirely on your own, or you can ask questions along the way of H&R Block staff. You can prepare your return and then have a company representative review it, correct as necessary and sign it as the preparer of record.

And you can participate in a videoconference remotely with a representative, just as if you'd walked into a physical H&R Block office. Starting with the 2012 tax year, you will be able to do the latter on your iPad, and you can maintain a year-round conversation with H&R Block experts, even saving relevant documents to a personal portal as you acquire them, so that you don't have such a mad scramble at prep time.

Interpreting the Arcane
Like TurboTax?and TaxACT, H&R Block At Home Deluxe Online helps you complete your 1040 and its related forms and schedules in a fashion that's much easier and more understandable than sitting at the kitchen table with a stack of paper forms and a lot of apprehension.

Over the years, H&R Block has continued to hone its web-based version of an in-person sit-down with a company representative. The live interview that you do when you visit one of the company's offices translates well to the approach that all tax preparation websites take: They ask you questions and provide fields or checklists or other conventions for your answers, and then they drop those answers in the correct fields on the actual IRS forms and schedules.

When you've answered all of the questions about your federal return, the service can use that information to work on any state returns required. The website does all of the calculating, and it combs your return for errors and omissions, insisting on correct responses before it lets you print the return or file it electronically.

Navigation is simple and straightforward. You advance through the interview by clicking "Back" and "Next" buttons (but the latter doesn't work unless you've completed the current screen, a departure from what competitors allow). A series of buttons in the upper right corner takes you to a chronological, interactive index of the site's topics; a utility that produces a link to the appropriate form when you enter a topic (new in the online version); your "bookmarks" (a list of pages where you've indicated you're missing information); and site utilities.

Help From the Pros
All of the tax sites we reviewed this year try to do three things primarily: help you fill out your forms as completely and accurately as you can; try to lower your tax obligation as much as is legally possible; and move you through the preparation process as quickly and painlessly as it can. So H&R Block, like its competitors, begins by asking for personal information (names, Social Security numbers, etc.) and then presenting you with a comprehensive list of the issues that are addressed within the IRS Form 1040 and its accompanying forms and schedules (employment wages, investments, interest income, mortgage interest, medical expenses, etc.). You check the ones that apply to you, and the step-by-step interview process begins.

As you go, H&R Block provides support for the challenging task. Some words and phrases within the site's interview questions are hyperlinked, and clicking on them opens a window containing a more complete explanation of what's needed there. Unlike in other sites, you can't click directly from there to get additional assistance, but a vertical pane to the right contains commonly-asked questions and answers about the current topic.

If that's not thorough enough for you, you can enter a search term in the box provided, which opens the Help Center. This window consists of a list of related help topics. There are often dozens of them, and they're not necessarily prioritized for general interest users?some are state-specific, and there's a lot of duplication. And many are answered in a sentence or two. You may have to do excessive clicking and reading to get your answer. Every other site offers more in-depth, easily-accessible, context-sensitive help.

When you click the "Go" button under "Need program help?" you're directed to a window that connects you to either a live chat session or a live phone call with an H&R Block support agent. This is for technical site support only. If you have a tax-related question, you only get one shot at a live chat, email and phone call, and then fees apply for each. This is in sharp contrast to TurboTax, which offers unlimited contact for free, and TaxACT, which charges $7.95 for unrestricted access. There's also online help and a community of users and experts asking and answering questions.

An Unusual Extra
H&R Block is making its huge stable of tax professionals available year-round now for ongoing support. It's giving customers their own private portal, where they can upload documentation for the current year's taxes. This is a great idea, and will be very helpful when prep time rolls around. The company will also provide tax law updates and advice from the pros on these individual sites.

H&R Block's online tax preparation sites have always been rated highly in our reviews. The variety of ways that you can interact with the company's experts is greater than what's offered by any competitor. But its online help tools pale in comparison to its competitors', and individualized tax help is prohibitively expensive.

If you've been using H&R Block At Home Deluxe or one of its sister sites (Free, Basic, and Premium) and you like it, there's no reason not to keep using it. It's an excellent site, backed up by the best-known name in tax preparation. But for the same price, you can get equally competent 1040 coverage with better onsite help and free remote access to tax experts through TurboTax Deluxe Online, our tax-prep Editors' Choice?the site I'll recommend this year to anyone who asks.

More Accouting and Tax Reviews:
??? H&R Block At Home Deluxe Online (Tax Year 2012)
??? Outright Plus
??? QuickBooks Premier Edition 2013
??? PayPal (for iPhone)
??? Pageonce (for Android)
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/US573KU_Y5s/0,2817,2414634,00.asp

khan academy Espn College Football Eddie Murphy died Suzanne Barr Clint Eastwood speech Maria Montessori clint eastwood

'Game of Thrones' season 3: Check out photos!

By Anna Chan, TODAY

Fans still have to wait until the end of March for the new season of "Game of Thrones" to air, but HBO is easing the long wait just a smidge by releasing 23 new photos from the highly anticipated season.?

Sure, favorite characters such as Arya, Joffrey (OK, maybe not so much the young king),?Dany and Tyrion are back again, but season three will also be introducing quite a few new faces. Among them are the Reed siblings Jojen and Meera, King Beyond the Wall Mance Rayder, the Queen of Thorns and many others.

Take a look!

HBO

Season three of "Game of Thrones" premieres March 31 on HBO.

Related content:?

More in The Clicker:

Source: http://theclicker.today.com/_news/2013/01/25/16702447-game-of-thrones-season-3-check-out-the-photos?lite

bby zimmerman website miami marlins marlins marlins facebook buys instagram kevin systrom

Friday, January 25, 2013

140 Proof Brings Its Interest-Targeted Ads To Tumblr And Other Blogging Platforms

140 proof tumblr140 Proof is expanding its social ad technology today with the launch of a new format called Native Ads for Social Sites, which allows 140 Proof advertisers to run campaigns on blogging platforms like WordPress and Tumblr. The company started out by using social data to determine user interests and then use those interests to target ads in social networking apps. The new native ad units also use 140 Proof's targeting technology, but by expanding to blogs, it's taking another step towards serving, in the company's words, "any publisher or media brand that wants to monetize social content, online or on mobile."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/un0Ji8WYogY/

super bowl matthew broderick tax refund calculator huntington disease west memphis three taxes game of thrones season 2 trailer

Samsung GT-N5110 passes through the FCC, leaves a Galaxy Note 8.0-size hole

Samsung GTN5110 passes through the FCC, matches Galaxy Note 80 rumors

Rumors (recently confirmed by company executives) have suggested Samsung would expand its lineup of stylus-packing mobile devices, and this GT-N5110 that just passed through the FCC fits the profile almost exactly. Sporting only WiFi and Bluetooth radios and described as a "personal tablet" it fits perfectly into the size hole between the existing Galaxy Note II and Galaxy Note 10.1 (check out a comparison of the dimensions after the break.)

The model number is also close to the Exynos 4 Quad powered GT-N5100 observed in benchmarks last month and another page in the document indicates it's sporting a matching 1.6GHz CPU. Looking back further, SamMobile spotted a GT-N5100/GT-N5110 certified for DLNA service back in the fall. The diagram listed in the FCC also seems to confirm recent picture leaks that show a device with a center mounted rear camera that looks more like the hot-selling Note II and less like most larger tablets. Hit the source link to dig through the documents for yourself, or just wait for more information which should be revealed in time for MWC 2013.


Samsung GTN5110 passes through the FCC, leaves a Galaxy Note 80size holeSamsung GTN5110 passes through the FCC, leaves a Galaxy Note 80size hole

Filed under: ,

Comments

Source: FCC

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/oUVGaSmT7Wg/

whitney houston dies dolly parton i will always love you beverly hilton hotel whitney houston found dead i will always love you whitney houston 2012 grammy awards powerball results

Maxing Out The Mini Season For Maine Shrimp

Trawlers in the Gulf of Maine are allowed to catch Maine shrimp during a limited season that started this week.

Gulf of Maine Research Institute

Trawlers in the Gulf of Maine are allowed to catch Maine shrimp during a limited season that started this week.

Gulf of Maine Research Institute

To Mainers, cold-water shrimp pulled from the Gulf of Maine in midwinter by a shrinking fleet of fisherman are many things: fresh, sweet, delicious, affordable, precious.

"The absolute best thing about them is that they are almost exclusively ours," boasts Portland-based architect and Maine shrimp lover Ric Quesada. He revels in the fact that Maine shrimp don't travel well out of state. "You don't run errands with these in your car. They want to go right home and be eaten," he says.

Upwards of 90 percent of the U.S. harvest of Pandalus borealis comes from the coast of Maine, with the remainder pulled in from waters off New Hampshire and Massachusetts.

The small crustaceans with bulbous black eyes are colloquially dubbed "salad shrimp" because of their 2- to 4-inch physiques and the frequency with which they top Caesar salads in Maine. Mainers contend their shrimp have a sweeter, more delicate flavor than those reared in the Gulf of Mexico or shipped in from Asia, most likely because of the colder water, they say.

The season for Maine shrimp is always fairly short, driven by the life cycle of these migratory hermaphrodites. Maggie Hunter, a scientist with the Maine Department of Marine Resources, says Maine shrimp sexually mature as males at about 2 1/2 years of age in the muddy bottoms of the deep, cold canyons of the Gulf of Maine. Roughly a year later, they transform into females and mating soon starts. When they are about four or five years-old, they migrate to slightly warmer waters closer to shore and there they spawn.

It's at that point in their lives, when the ladies approach the shore between December and February, that they are caught for Mainers' consumption.

But this year Mainers are going to be consuming much less shrimp than they have in the past. The season is starting late to allow more shrimp to spawn before they are caught. And in December, regulators set the allowable catch for the species at just 72 percent of the 2012 level.

The overall allowable catch is divided between fishermen that drag nets behind their boats (a process called trawling) and fishermen that use traps. The season for trawlers began on Jan. 23, and they're only allowed to shrimp on Mondays and Wednesday mornings. Fisherman using traps ? which typically bring in more uniformly sized shrimp because holes in the trap let the little ones escape ? can't begin their shrimping until Feb. 5.

Maine shrimp are small and more red than pink. Mainers say the shrimp have a sweeter, more delicate flavor than shrimp from the American south or Asia.

courtesy Gulf of Maine Research Institute

Maine shrimp are small and more red than pink. Mainers say the shrimp have a sweeter, more delicate flavor than shrimp from the American south or Asia.

courtesy Gulf of Maine Research Institute

How long the season will last is anyone's guess as weather and the shrimpers' ability to locate the shrimp both play a role. Estimates range up to to six weeks, but many think it will be a lot shorter.

If early sales are any indication, the shrimp haul won't last long in the shops. Harbor Fish in Portland received 180 pounds of shrimp on the 23rd at 11:30 a.m., and sold out in less than three hours.

The Atlantic States Marine Fisheries Commission, which regulates the fishery, contends the limits are necessary because the little gals have been overfished for the last three years, all surveys of the Maine shrimp population are trending downward and there are alarmingly few shrimp mature enough to make the migration to the shore.

The hope is that cutting back on the allowable catch will allow the fishery to return to sustainable levels. But recent samples don't bode well for a quick turnaround, Hunter says.

Sammy Viola is a commercial fisherman who has shrimped out of Maine's Portland Harbor on and off since 1994. He says catch limits are unnecessary. "Maine shrimp are so sensitive to both water temperature and salinity that they are either going to be there or not be there," he says. "If they are not there from one year to the next, we can't catch them, can we?"

Viola says he'll cast his shrimp nets this season, lured by a wholesale price for whole shrimp that's about 50 cents higher per pound than last year. But he also fears that if he doesn't go shrimping this year, regulators will decide to ban him next year. Regulators have made no calls yet about the 2014 season, but the previous year's haul does sometimes factor into the determination of an individual fisherman's quotas for other species, like cod.

Quotas aside, Mainers offer plenty of advice on how they plan to prepare as much of the rare Maine shrimp as they can get their hands on.

Viola will eat some raw on his boat. "They crunch like popcorn," he says.

Quesada first brines them in a salt solution and then marinates them very quickly in olive oil, garlic, herbs and cayenne pepper. He arranges them whole on a very hot, cast iron plancha, turns them once and then calls his family over.

"They should be eaten at the stove. Bringing them to the table is almost wasted effort," he says.

Shrimp cookers all admit to freezing some of the meats for future use and some of the shells for stock. But they say that frozen Maine shrimp isn't quite the same as fresh.

When Quesada pulls a half pound bag from the freezer, he only employs them as a garnish, for paella or on seafood pasta, for example.

"It's just a little hocus pocus I do to conjure up the image of the real Maine shrimp season," he says.

Christine Burns Rudalevige is a food writer and recipe developer who recently relocated to Maine and is currently enjoying her first shrimp season there.

Source: http://www.npr.org/blogs/thesalt/2013/01/24/170157716/maxing-out-the-mini-season-for-maine-shrimp?ft=1&f=1007

marco rubio farrah abraham Paul Ryan Speech chris cooley chris cooley condoleezza rice Perry Hall High School

Thursday, January 24, 2013

N.M. teen spends time at church after family slain

ALBUQUERQUE, N.M. (AP) ? The New Mexico teen accused of killing his family and plotting to randomly gun down Wal-Mart shoppers spent much of the day after the early morning slayings at his church, wandering the campus as dozens of Sunday school teachers were being trained on how to deal with a shooter, a security official said.

But it wasn't until hours later, former police officer and Calvary Albuquerque security chief Vince Harrison said, that he knew something had gone terribly wrong.

Harrison, who led the safety training Saturday morning, said he was called back to the church that evening after 15-year-old Nehemiah Griego told a pastor he found his family dead in their home.

"When I met Nehemiah, I knew something wasn't right," Harrison said Wednesday. "I could feel it, I could see it in his eyes and I could see it in his behavior and his demeanor so the red flags went up and that's when I called the sheriff's department."

Harrison, who had known the Griego family for about 10 years, said he drove the teen back to the family's rural southwest Albuquerque home to meet authorities, interviewing him along the way.

"He went into detail of where they were, where the guns were and he was very matter-of-fact, really cold so I knew something wasn't right," Harrison said.

After finding the bodies, sheriff's officials say, they took the teen to headquarters. During questioning, they say he confessed to shooting his mother and three younger siblings in their beds shortly after 1 a.m., then waiting in a bathroom with a military-style semi-automatic rifle to ambush his father upon his return from an overnight shift at a homeless shelter.

They say he also told them he had reloaded the family's rifles and taken them with him in the family van with plans to randomly shoot more people.

"That sends chills down my spine," Harrison said. "But obviously God had a different plan."

Harrison said several people spotted Griego at the church throughout the day and told him hello, thinking nothing of it until his arrest. He said officials then reviewed security video and found the teen had spent much of the day there.

The video has been turned over to investigators, who have been working to piece together what led to the violence and what happened in the hours that followed.

Harrison said he doesn't know why Griego decided to come to the church, but that it was like a second home for the boy, who was homeschooled.

"It was a familiar place to him," he said. "I think if he did have in his mindset to do something foolish and start shooting people there also, I think his demeanor was tamed a little bit because he saw people there he knew."

Sheriff Dan Houston said Tuesday there was no indication Griego intended to harm anyone at the church. The sheriff also said Griego and his girlfriend had spent much of the day together.

A prayer vigil was held at the church Wednesday night for victims Greg Griego, 51, his wife, Sarah Griego, 40, and three of their children ? a 9-year-old boy, Zephania Griego, and daughters Jael Griego, 5, and Angelina Griego, 2.

Before the start of the vigil, members of the crowd shared hugs and handshakes as photographs of the victims were displayed on large digital screens at the front of the church. An estimated 2,000 people attended and nearly every seat was filled before the start of the hour-long service.

"Our hearts break, Lord," Pastor Skip Heitzig told the crowd. "We, often in times like these, scratch our heads and wonder why. We are at a loss for words and we are certainly at a loss for explanation."

Heitzig shared stories about Greg Griego, who once served as pastor at Calvary. He said Greg was always ready to "get his hands dirty" and was dedicated to helping others find God through his work as a pastor and as a volunteer chaplain. He also urged the crowd to remember that forgiveness and restoration ? two tenets dear to Greg ? will be important as the community moves forward.

Relatives in a statement Tuesday night said they were heartbroken, and remembered the teen as a bright and talented musician who played guitar, drums and bass with the church choir. He also was a champion wrestler who dreamed of following his family's long tradition of military service, and a boy who accompanied his pastor father on rescue missions to Mexico, they said.

"We have not been able to comprehend what led to this incredibly sad situation. However, we are deeply concerned about the portrayal in some media of Nehemiah as some kind of a monster."

The statement, emailed by the boy's uncle, Eric Griego, called on the media and the public not to use 15-year-old Nehemiah Griego "as a pawn for ratings or to score political points."

"He is a troubled young man who made a terrible decision that will haunt him and his family forever," the statement said.

___

Associated Press Writer Jeri Clausing in Albuquerque, N.M., contributed to this report.

___

Follow Susan Montoya Bryan on Twitter: http://www.twitter.com/susanmbryanNM

Source: http://news.yahoo.com/nm-teen-spends-time-church-family-slain-044758821.html

how to tie a tie sweet potato recipes the sound of music celebration church new york auto show 2012 tulsa easter eggs

Wind, snow thwart search for plane in Antarctica

(AP) ? Hurricane-force winds and snow were preventing searchers Friday from reaching a plane believed to have crashed in an Antarctic mountain range while carrying three Canadians.

Its emergency locator started transmitting late Wednesday about 680 kilometers (420 miles) north of the South Pole, but the weather has prevented search planes overhead from seeing the presumed crash site itself.

Rescuers don't know if the men are alive. Their plane has survival gear including tents and food.

The locator stopped transmitting Thursday night and crews have been unable to establish radio contact. Rescuers say a break in the weather is forecast Saturday.

One man on the plane has been identified as Bob Heath from the Northwest Territories, an experienced pilot in both the Antarctic and Arctic. Rescuers say the other two men were also part of the flight crew and that no passengers were aboard.

The propeller-driven de Havilland Twin Otter, was flying from a U.S. station near the pole to an Italian research base in Terra Nova Bay. Rescuers believe it crashed in the Queen Alexandra mountain range at an elevation of about 3,900 meters (13,000 feet).

Winds of up to 90 knots (104 miles per hour) have been blowing Thursday and Friday.

Steve Rendle, a spokesman for New Zealand's Rescue Coordination Centre, said rescue planes circled the area on Thursday and Friday but have been unable to spot the downed plane due to poor visibility. He said the battery on the locator beacon may have run out but that rescuers have a good fix on its location.

He said that when the weather clears, crews hope to establish a forward base at the Beardmore Glacier about 50 kilometers (30 miles) from the assumed crash site. He said there's a rudimentary runway and a fuel depot at the glacier.

For now, two helicopters and a small plane remain at McMurdo Station, the main U.S. base about four hours' flight away. He said the elevation provides extra challenges for helicopter crews.

Heath's wife, Lucy Heath, told the Calgary Sun newspaper that airline officials had told her her husband's plane was down, and she said she was just waiting for more news: "I'm so worried."

Bob Heath wrote on networking site LinkedIn that he typically spends this time of year coaching and mentoring other pilots in polar regions.

The missing plane is owned and operated by Kenn Borek Air Ltd., a Calgary firm that charters aircraft to the U.S. Antarctic program. In a release, the National Science Foundation said the plane was flying in support of the Italian Antarctic program.

Authorities from New Zealand, Canada, the U.S. and Italy are working on the rescue operation.

Antarctica has no permanent residents, but several thousand people live there in the Southern Hemisphere summer as a number of countries send scientists and other staff to research stations. The U.S. runs the largest program, with about 850 staff at its McMurdo Station and another 200 at its Amundsen-Scott South Pole Station, where the Canadians' flight originated.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-01-24-Antarctica-Plane%20Missing/id-c2c1fbf5de5f43b69f3f1181b00427c4

Holly Rowe Chief Keef Jodi Arias FRANK ZAMBONI Tiffany Six aaliyah jodie foster

Scientists discover how epigenetic information could be inherited: Mechanism of epigenetic reprogramming revealed

Jan. 24, 2013 ? New research reveals a potential way for how parents' experiences could be passed to their offspring's genes. The research was published January, 25 in the journal Science.

Epigenetics is a system that turns our genes on and off. The process works by chemical tags, known as epigenetic marks, attaching to DNA and telling a cell to either use or ignore a particular gene.

The most common epigenetic mark is a methyl group. When these groups fasten to DNA through a process called methylation they block the attachment of proteins which normally turn the genes on. As a result, the gene is turned off.

Scientists have witnessed epigenetic inheritance, the observation that offspring may inherit altered traits due to their parents' past experiences. For example, historical incidents of famine have resulted in health effects on the children and grandchildren of individuals who had restricted diets, possibly because of inheritance of altered epigenetic marks caused by a restricted diet.

However, it is thought that between each generation the epigenetic marks are erased in cells called primordial gene cells (PGC), the precursors to sperm and eggs. This 'reprogramming' allows all genes to be read afresh for each new person -- leaving scientists to question how epigenetic inheritance could occur.

The new Cambridge study initially discovered how the DNA methylation marks are erased in PGCs, a question that has been under intense investigation over the past 10 years. The methylation marks are converted to hydroxymethylation which is then progressively diluted out as the cells divide. This process turns out to be remarkably efficient and seems to reset the genes for each new generation. Understanding the mechanism of epigenetic resetting could be exploited to deal with adult diseases linked with an accumulation of aberrant epigenetic marks, such as cancers, or in 'rejuvenating' aged cells.

However, the researchers, who were funded by the Wellcome Trust, also found that some rare methylation can 'escape' the reprogramming process and can thus be passed on to offspring -- revealing how epigenetic inheritance could occur. This is important because aberrant methylation could accumulate at genes during a lifetime in response to environmental factors, such as chemical exposure or nutrition, and can cause abnormal use of genes, leading to disease. If these marks are then inherited by offspring, their genes could also be affected.

Dr Jamie Hackett from the University of Cambridge, who led the research, said: "Our research demonstrates how genes could retain some memory of their past experiences, revealing that one of the big barriers to the theory of epigenetic inheritance -- that epigenetic information is erased between generations -- should be reassessed."

"It seems that while the precursors to sperm and eggs are very effective in erasing most methylation marks, they are fallible and at a low frequency may allow some epigenetic information to be transmitted to subsequent generations. The inheritance of differential epigenetic information could potentially contribute to altered traits or disease susceptibility in offspring and future descendants."

"However, it is not yet clear what consequences, if any, epigenetic inheritance might have in humans. Further studies should give us a clearer understanding of the extent to which heritable traits can be derived from epigenetic inheritance, and not just from genes. That could have profound consequences for future generations."

Professor Azim Surani from the University of Cambridge, principal investigator of the research, said: "The new study has the potential to be exploited in two distinct ways. First, the work could provide information on how to erase aberrant epigenetic marks that may underlie some diseases in adults. Second, the study provides opportunities to address whether germ cells can acquire new epigenetic marks through environmental or dietary influences on parents that may evade erasure and be transmitted to subsequent generations, with potentially undesirable consequences."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Cambridge, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J. A. Hackett, R. Sengupta, J. J. Zylicz, K. Murakami, C. Lee, T. A. Down, M. A. Surani. Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine. Science, 2012; DOI: 10.1126/science.1229277

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/6OaEQm9fXYc/130124150808.htm

whitney houston casket photo match play championship the national enquirer marie colvin cm punk cm punk lint

Monday, January 21, 2013

North Korea allows tourists to rent phones or SIM cards, but doesn't include internet

North Korea allows tourists to rent phones or SIM cards, but doesn't include internet

North Korea (which recently added Google's Eric Schmidt to its guest book) will begin loosening its restrictions on foreign cellphones, allowing any arrivals to either pick up a rental phone or SIM card from service provider Koryolink. With a rental booth already set up in Pyongyang airport, you'll be able to dial out to numbers abroad, foreign embassies and international hotels. However, the SIMs (priced at around $67) won't allow you to call locals, nor will they offer any internet data -- not even EDGE. Apparently, providing data to the rental SIMs in North Korea wouldn't be a technical issue, but is dependent on whether it's granted approval by the DPRK government.

Image credit: Wikipedia Creative Commons

Filed under: , ,

Comments

Via: The Verge

Source: AP (The Guardian), Xinhua

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/eRQp2EVCMbE/

mega millions results louisville lotto numbers susan powell megamillions winners university of louisville louisville ky

Enzyme helps cancer cells avoid genetic instability

Enzyme helps cancer cells avoid genetic instability [ Back to EurekAlert! ] Public release date: 21-Jan-2013
[ | E-mail | Share Share ]

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the January 21st issue of The Journal of Cell Biology.

The BRCA1 protein helps to mend double-strand DNA breaks by promoting homologous recombination. Without it, cells can amass broken, jumbled, and fused chromosomes, which may cause them to stop growing or die. Although cells lacking BRCA1 seem like they should be vulnerable, loss of the protein instead seems to boost abnormal growth.

Recent studies have shown that cells lacking BRCA1 compensate by cutting back on 53BP1. This protein helps orchestrate a different DNA repair mechanism, nonhomologous end joining (NHEJ), and it thwarts a key step in homologous recombination. Researchers think that, in cells without BRCA1, 53BP1 spurs excessive NHEJ that can cause fatal chromosomal chaos. But with 53BP1 out of the way, the cells are able to resume homologous recombination. That might explain why cells that lack BRCA1 and eliminate 53BP1 can withstand traditional chemotherapy compounds and PARP inhibitors, a new generation of anti-cancer drugs that are in clinical trials. But how do cancer cells turn down 53BP1?

Researchers previously found that certain mutant fibroblasts increase production of cathepsin L, a protease that destroys 53BP1. BRCA1-deficient cancer cells take advantage of the same mechanism, according to a team of researchers led by Susana Gonzalo from the Washington University School of Medicine. When they cultured breast cancer cells that were missing BRCA1, the cells stopped growing. After two weeks of lethargy, however, some cells, which the researchers dubbed BOGA cells (BRCA1-deficient cells that overcome growth arrest), began to divide again. These cells showed increased levels of cathepsin L and reduced amounts of 53BP1. Eliminating cathepsin L from BOGA cells or dosing them with vitamin D, a cathepsin L inhibitor, prevented the decline in 53BP1 abundance.

To find out whether boosting cathepsin L levels enabled the cancer cells to restart homologous recombination, the researchers monitored sites of DNA damage tagged by RAD51, a protein that helps promote homologous recombination. The cells that had stopped growing did not display RAD51 foci, but these foci were prevalent in BOGA cells with reduced 53BP1. Removing cathepsin L from BOGA cells increased 53BP1 levels and diminished the number of RAD51 foci.

If cells can't perform homologous recombination, they turn to repair mechanisms such as NHEJ that can lead to jumbled chromosomes. However, after DNA-breaking doses of radiation, BOGA cells exhibited few chromosome defects. The number of these flaws climbed after the researchers stabilized 53BP1 levels by inhibiting cathepsin L or trimming its abundance.

The team then analyzed tumor samples from breast cancer patients. Researchers suspect that cathepsin L attacks 53BP1 by entering the nucleus. Samples from patients with BRCA1 mutations or with triple-negative breast canceran aggressive form of the diseaseshowed high levels of nuclear cathepsin L and reduced quantities of 53BP1. That suggests tumors in these patients hike the amounts of cathepsin L in the nucleus to break down 53BP1 and restore homologous recombination.

"It's a new pathway that explains how breast cancer cells lose 53BP1," says Gonzalo. How cancer cells boost nuclear cathepsin L levels is unclear, she notes.

Triple-negative breast cancers are currently identified by their lack of Her2 and the estrogen and progesterone receptors. The work suggests that another trio of measurementsthe amounts of 53BP1, cathepsin L, and vitamin D receptor in the nucleusmight help identify patients that are resistant to current breast cancer treatments. These people might respond to cathepsin inhibitors, some of which are undergoing animal testing. These compounds might steer the cells away from homologous recombination and leave them vulnerable to other therapies.

###

Grotsky, D.A., et al. 2013. J. Cell Biol. doi:10.1083/jcb.201204053.

About The Journal of Cell Biology (JCB) JCB is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JCB content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works, and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit www.jcb.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Enzyme helps cancer cells avoid genetic instability [ Back to EurekAlert! ] Public release date: 21-Jan-2013
[ | E-mail | Share Share ]

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the January 21st issue of The Journal of Cell Biology.

The BRCA1 protein helps to mend double-strand DNA breaks by promoting homologous recombination. Without it, cells can amass broken, jumbled, and fused chromosomes, which may cause them to stop growing or die. Although cells lacking BRCA1 seem like they should be vulnerable, loss of the protein instead seems to boost abnormal growth.

Recent studies have shown that cells lacking BRCA1 compensate by cutting back on 53BP1. This protein helps orchestrate a different DNA repair mechanism, nonhomologous end joining (NHEJ), and it thwarts a key step in homologous recombination. Researchers think that, in cells without BRCA1, 53BP1 spurs excessive NHEJ that can cause fatal chromosomal chaos. But with 53BP1 out of the way, the cells are able to resume homologous recombination. That might explain why cells that lack BRCA1 and eliminate 53BP1 can withstand traditional chemotherapy compounds and PARP inhibitors, a new generation of anti-cancer drugs that are in clinical trials. But how do cancer cells turn down 53BP1?

Researchers previously found that certain mutant fibroblasts increase production of cathepsin L, a protease that destroys 53BP1. BRCA1-deficient cancer cells take advantage of the same mechanism, according to a team of researchers led by Susana Gonzalo from the Washington University School of Medicine. When they cultured breast cancer cells that were missing BRCA1, the cells stopped growing. After two weeks of lethargy, however, some cells, which the researchers dubbed BOGA cells (BRCA1-deficient cells that overcome growth arrest), began to divide again. These cells showed increased levels of cathepsin L and reduced amounts of 53BP1. Eliminating cathepsin L from BOGA cells or dosing them with vitamin D, a cathepsin L inhibitor, prevented the decline in 53BP1 abundance.

To find out whether boosting cathepsin L levels enabled the cancer cells to restart homologous recombination, the researchers monitored sites of DNA damage tagged by RAD51, a protein that helps promote homologous recombination. The cells that had stopped growing did not display RAD51 foci, but these foci were prevalent in BOGA cells with reduced 53BP1. Removing cathepsin L from BOGA cells increased 53BP1 levels and diminished the number of RAD51 foci.

If cells can't perform homologous recombination, they turn to repair mechanisms such as NHEJ that can lead to jumbled chromosomes. However, after DNA-breaking doses of radiation, BOGA cells exhibited few chromosome defects. The number of these flaws climbed after the researchers stabilized 53BP1 levels by inhibiting cathepsin L or trimming its abundance.

The team then analyzed tumor samples from breast cancer patients. Researchers suspect that cathepsin L attacks 53BP1 by entering the nucleus. Samples from patients with BRCA1 mutations or with triple-negative breast canceran aggressive form of the diseaseshowed high levels of nuclear cathepsin L and reduced quantities of 53BP1. That suggests tumors in these patients hike the amounts of cathepsin L in the nucleus to break down 53BP1 and restore homologous recombination.

"It's a new pathway that explains how breast cancer cells lose 53BP1," says Gonzalo. How cancer cells boost nuclear cathepsin L levels is unclear, she notes.

Triple-negative breast cancers are currently identified by their lack of Her2 and the estrogen and progesterone receptors. The work suggests that another trio of measurementsthe amounts of 53BP1, cathepsin L, and vitamin D receptor in the nucleusmight help identify patients that are resistant to current breast cancer treatments. These people might respond to cathepsin inhibitors, some of which are undergoing animal testing. These compounds might steer the cells away from homologous recombination and leave them vulnerable to other therapies.

###

Grotsky, D.A., et al. 2013. J. Cell Biol. doi:10.1083/jcb.201204053.

About The Journal of Cell Biology (JCB) JCB is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JCB content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works, and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit www.jcb.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/rup-ehc011813.php

irs CES russell wilson Pokemon downton abbey nhl jillian michaels